CHMP4B

GENE INFORMATION

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Gene name

CHMP4B (HGNC Symbol)

Synonyms

C20orf178, dJ553F4.4, Shax1, SNF7-2, VPS32B

Description

charged multivesicular body protein 4B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]

Chromosome

20 (Chromosome progress)

Cytoband

q11.22

Chromosome location (bp)

32399110 - 32442172

Ensembl

ENSG00000101421 (version 73.37)

Entrez gene

128866

UniProt

Q9H444 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H444

Antibodypedia

CHMP4B antibodies
 

PROTEIN VIEW

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CHMP4B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHMP4B-001 ENSP00000217402
ENST00000217402
Q9H444
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