MID1

GENERAL INFORMATION

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Gene name

MID1

Gene description

Midline 1

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic staining was observed in astrocytes of the CNS and in neuroendocrine cells. Purkinje cells and fraction of neuronal cells showed distinct nuclear staining. Most other normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003715
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

MID1 (HGNC Symbol)

Synonyms

FXY, OS, RNF59, TRIM18

Description

Midline 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined. [provided by RefSeq, Jul 2010]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

10445310 - 10833654

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101871 (version 78.38)

Entrez gene

4281

UniProt

O15344 (UniProt - Evidence at protein level)

neXtProt

NX_O15344

Antibodypedia

MID1 antibodies


PROTEIN BROWSER

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ENST00000317552
 
ENST00000380779
 
ENST00000380780
 
ENST00000380782
 
ENST00000380785
 
ENST00000380787
 
ENST00000413894
 
ENST00000423614
 
ENST00000453318
 
ENST00000610939
 
ENST00000616003
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MID1-001 ENSP00000370162
ENST00000380785
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-002 ENSP00000387771
ENST00000423614
C9JZJ7
Show all »
Show » Show » 197 22.1 No 0
MID1-003 ENSP00000370156
ENST00000380779
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-004 ENSP00000391154
ENST00000413894
C9J453
Show all »
Show » Show » 483 54.5 No 0
MID1-005 ENSP00000370164
ENST00000380787
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-006 ENSP00000370157
ENST00000380780
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-007 ENSP00000370159
ENST00000380782
O15344
Show all »
Show » Show » 552 62.3 No 0
MID1-201 ENSP00000312678
ENST00000317552
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-202 ENSP00000414521
ENST00000453318
O15344
Show all »
Show » Show » 667 75.3 No 0
MID1-203 ENSP00000483707
ENST00000610939
Show » Show » 228 25.7 No 0
MID1-204 ENSP00000484712
ENST00000616003
C9JZJ7
Show all »
Show » Show » 540 61.7 No 1