F9

GENE INFORMATION

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Gene name

F9 (HGNC Symbol)

Synonyms

FIX

Description

coagulation factor IX (HGNC Symbol)

Entrez gene summary

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q27.1

Chromosome location (bp)

138612917 - 138645617

Ensembl

ENSG00000101981 (version 73.37)

Entrez gene

2158

UniProt

P00740 (UniProt - Evidence at protein level)

neXtProt

NX_P00740

Antibodypedia

F9 antibodies
 

PROTEIN VIEW

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F9-001
 
F9-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F9-001 ENSP00000218099
ENST00000218099
P00740
Show all »
Show » Show » 461 51.8 Yes 0
F9-201 ENSP00000377650
ENST00000394090
Q5FBE1
Show all »
Show » Show » 423 47.6 Yes 0