HTR2A

GENE INFORMATION

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Gene name

HTR2A (HGNC Symbol)

Synonyms

5-HT2A, HTR2

Description

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled (HGNC Symbol)

Entrez gene summary

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

13 (Chromosome progress)

Cytoband

q14.2

Chromosome location (bp)

47405685 - 47471169

Ensembl

ENSG00000102468 (version 73.37)

Entrez gene

3356

UniProt

P28223 (UniProt - Evidence at protein level)

neXtProt

NX_P28223

Antibodypedia

HTR2A antibodies
 

PROTEIN VIEW

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HTR2A-001
 
HTR2A-201
 
HTR2A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTR2A-001 ENSP00000367959
ENST00000378688
P28223
Show all »
Show » Show » 471 52.6 No 7
HTR2A-201 ENSP00000437737
ENST00000542664
P28223
Show all »
Show » Show » 471 52.6 No 7
HTR2A-202 ENSP00000441861
ENST00000543956
B3VRB0
Show all »
Show » Show » 387 43.9 No 5