ARHGEF7

GENERAL INFORMATION

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Gene name

ARHGEF7

Gene description

Rho guanine nucleotide exchange factor (GEF) 7

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA004744
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ARHGEF7 (HGNC Symbol)

Synonyms

BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB

Description

Rho guanine nucleotide exchange factor (GEF) 7 (HGNC Symbol)

Entrez gene summary

Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q34

Chromosome location (bp)

111114559 - 111305737

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102606 (version 78.38)

Entrez gene

8874

UniProt

Q14155 (UniProt - Evidence at protein level)

neXtProt

NX_Q14155

Antibodypedia

ARHGEF7 antibodies


PROTEIN BROWSER

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ENST00000218789
 
ENST00000317133
 
ENST00000375723
 
ENST00000375736
 
ENST00000375739
 
ENST00000375741
 
ENST00000426073
 
ENST00000426768
 
ENST00000449979
 
ENST00000466143
 
ENST00000467053
 
ENST00000478679
 
ENST00000491775
 
ENST00000544132
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF7-001 ENSP00000218789
ENST00000218789
B1ALK7
Show all »
Show » Show » 705 79.8 No 0
ARHGEF7-003 ENSP00000406732
ENST00000449979
B1ANY6
Show all »
Show » Show » 66 7.6 No 0
ARHGEF7-004 ENSP00000397068
ENST00000426073
Q14155
Show all »
Show » Show » 646 73.1 No 0
ARHGEF7-005 ENSP00000364875
ENST00000375723
Q14155
Show all »
Show » Show » 625 70.4 No 0
ARHGEF7-007 ENSP00000364888
ENST00000375736
Q14155
Show all »
Show » Show » 646 73.1 No 0
ARHGEF7-008 ENSP00000325994
ENST00000317133
Q14155
Show all »
Show » Show » 782 87.8 No 0
ARHGEF7-009 ENSP00000389890
ENST00000426768
E7ENL8
Show all »
Show » Show » 143 16 No 0
ARHGEF7-011 ENSP00000417596
ENST00000478679
E9PDQ5
Show all »
Show » Show » 547 61.6 No 0
ARHGEF7-013 ENSP00000418067
ENST00000466143
E7EUY6
Show all »
Show » Show » 447 50.5 No 0
ARHGEF7-015 ENSP00000418043
ENST00000491775
C9JAD7
Show all »
Show » Show » 39 4.5 No 0
ARHGEF7-016 ENSP00000420592
ENST00000467053
C9JDI6
Show all »
Show » Show » 61 7.1 No 0
ARHGEF7-018 ENSP00000445384
ENST00000544132
Show » 130 14.5 No 0
ARHGEF7-201 ENSP00000364891
ENST00000375739
Q14155
Show all »
Show » Show » 753 84.5 No 0
ARHGEF7-202 ENSP00000364893
ENST00000375741
Q14155
Show all »
Show » Show » 803 90 No 0