PARP4

GENERAL INFORMATION

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Gene name

PARP4

Gene description

Poly (ADP-ribose) polymerase family, member 4

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, additional expression in lymphoid cells in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA011739
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PARP4 (HGNC Symbol)

Synonyms

ADPRTL1, p193, VAULT3, VPARP, VWA5C

Description

Poly (ADP-ribose) polymerase family, member 4 (HGNC Symbol)

Entrez gene summary

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q12.12

Chromosome location (bp)

24420926 - 24512810

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102699 (version 78.38)

Entrez gene

143

UniProt

Q9UKK3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKK3

Antibodypedia

PARP4 antibodies


PROTEIN BROWSER

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ENST00000381989
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARP4-001 ENSP00000371419
ENST00000381989
Q9UKK3
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