SLC25A15

GENERAL INFORMATION

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Gene name

SLC25A15

Gene description

Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

Protein class

Disease related genes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA042146
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SLC25A15 (HGNC Symbol)

Synonyms

D13S327, HHH, ORC1, ORNT1

Description

Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (HGNC Symbol)

Entrez gene summary

This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]

Chromosome

13

Cytoband

q14.11

Chromosome location (bp)

40789412 - 40810111

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102743 (version 78.38)

Entrez gene

10166

UniProt

Q9Y619 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y619

Antibodypedia

SLC25A15 antibodies


PROTEIN BROWSER

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ENST00000338625
 
ENST00000417731
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC25A15-001 ENSP00000415826
ENST00000417731
Q5VZD9
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Show » Show » 133 14.4 No 0
SLC25A15-005 ENSP00000342267
ENST00000338625
Q9Y619
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Show » Show » 301 32.7 No 2