FLT1

GENE INFORMATION

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Gene name

FLT1 (HGNC Symbol)

Synonyms

FLT, VEGFR1

Description

fms-related tyrosine kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Chromosome

13 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

28874489 - 29069265

Ensembl

ENSG00000102755 (version 73.37)

Entrez gene

2321

UniProt

P17948 (UniProt - Evidence at protein level)

neXtProt

NX_P17948

Antibodypedia

FLT1 antibodies
 

PROTEIN VIEW

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FLT1-001
 
FLT1-201
 
FLT1-202
 
FLT1-203
 
FLT1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLT1-001 ENSP00000282397
ENST00000282397
P17948
Show all »
Show » Show » 1338 150.8 Yes 1
FLT1-201 ENSP00000442630
ENST00000539099
P17948
Show all »
Show » Show » 541 60.9 Yes 0
FLT1-202 ENSP00000443311
ENST00000540678
P17948
Show all »
Show » Show » 556 63 No 0
FLT1-203 ENSP00000437631
ENST00000541932
P17948
Show all »
Show » Show » 733 82.1 Yes 0
FLT1-204 ENSP00000437841
ENST00000543394
B2BF48
Show all »
Show » 361 41.2 No 0