STUB1

GENERAL INFORMATION

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Gene name

STUB1

Gene description

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 4 antibodies.
HPA041222 , HPA043531 , CAB037202 , CAB037209
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

STUB1 (HGNC Symbol)

Synonyms

CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1

Description

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

680224 - 682870

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103266 (version 78.38)

Entrez gene

10273

UniProt

Q9UNE7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UNE7

Antibodypedia

STUB1 antibodies


PROTEIN BROWSER

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ENST00000219548
 
ENST00000564316
 
ENST00000564370
 
ENST00000565677
 
ENST00000566408
 
ENST00000567173
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STUB1-001 ENSP00000219548
ENST00000219548
Q9UNE7
Show all »
Show » Show » 303 34.9 No 0
STUB1-002 ENSP00000457228
ENST00000565677
Q9UNE7
Show all »
Show » Show » 231 27.1 No 0
STUB1-004 ENSP00000456591
ENST00000567173
H3BS86
Show all »
Show » Show » 214 24.5 No 0
STUB1-008 ENSP00000456875
ENST00000564370
Q9UNE7
Show all »
Show » Show » 231 27.1 No 0
STUB1-010 ENSP00000457583
ENST00000566408
Show » Show » 185 21.4 No 0
STUB1-011 ENSP00000457090
ENST00000564316
Show » Show » 157 18.4 No 0