PIEZO1

GENERAL INFORMATION

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Gene name

PIEZO1

Gene description

Piezo-type mechanosensitive ion channel component 1

Protein class

Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Neuropil showed distinct immunoreactivity. Remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA047185
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PIEZO1 (HGNC Symbol)

Synonyms

FAM38A, KIAA0233

Description

Piezo-type mechanosensitive ion channel component 1 (HGNC Symbol)

Entrez gene summary

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]

Chromosome

16

Cytoband

q24.3

Chromosome location (bp)

88715343 - 88785211

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103335 (version 78.38)

Entrez gene

9780

UniProt

Q92508 (UniProt - Evidence at protein level)

neXtProt

NX_Q92508

Antibodypedia

PIEZO1 antibodies


PROTEIN BROWSER

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ENST00000301015
 
ENST00000327397
 
ENST00000466823
 
ENST00000474606
 
ENST00000518793
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIEZO1-001 ENSP00000301015
ENST00000301015
Q92508
Show all »
Show » Show » 2521 286.8 No >9
PIEZO1-009 ENSP00000428673
ENST00000474606
Show » 182 20.4 No 0
PIEZO1-015 ENSP00000456680
ENST00000518793
Show » 35 3.8 No 0
PIEZO1-017 ENSP00000456373
ENST00000466823
Show » Show » 184 21.5 No 3
PIEZO1-201 ENSP00000333704
ENST00000327397
E7EUT2
Show all »
Show » Show » 373 41.3 No 1