BCKDK

GENERAL INFORMATION

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Gene name

BCKDK

Gene description

Branched chain ketoacid dehydrogenase kinase

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA017995
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BCKDK

Synonyms

Description

Branched chain ketoacid dehydrogenase kinase (HGNC Symbol)

Entrez gene summary

The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

31106107 - 31112791

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103507 (version 78.38)

Entrez gene

10295

UniProt

O14874 (UniProt - Evidence at protein level)

neXtProt

NX_O14874

Antibodypedia

BCKDK antibodies


PROTEIN BROWSER

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ENST00000219794
 
ENST00000287507
 
ENST00000394950
 
ENST00000394951
 
ENST00000484226
 
ENST00000561755
 
ENST00000567676
 
ENST00000567682
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCKDK-001 ENSP00000219794
ENST00000219794
O14874
Show all »
Show » Show » 412 46.4 No 0
BCKDK-002 ENSP00000378404
ENST00000394950
O14874
Show all »
Show » Show » 365 41.1 No 0
BCKDK-003 ENSP00000287507
ENST00000287507
O14874
Show all »
Show » Show » 335 37.8 No 0
BCKDK-004 ENSP00000378405
ENST00000394951
O14874
Show all »
Show » Show » 412 46.4 No 0
BCKDK-007 ENSP00000455866
ENST00000561755
H3BQP2
Show all »
Show » 60 6.4 No 0
BCKDK-008 ENSP00000454947
ENST00000567676
H3BNP3
Show all »
Show » 88 9.4 No 0
BCKDK-009 ENSP00000457821
ENST00000567682
Show » 146 15.3 No 0
BCKDK-010 ENSP00000457226
ENST00000484226
H3BTL2
Show all »
Show » 217 24.3 No 0