IL21R

GENE INFORMATION

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Gene name

IL21R (HGNC Symbol)

Synonyms

CD360

Description

interleukin 21 receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

Chromosome

16 (Chromosome progress)

Cytoband

p12.1

Chromosome location (bp)

27413483 - 27462115

Ensembl

ENSG00000103522 (version 73.37)

Entrez gene

50615

UniProt

Q9HBE5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBE5

Antibodypedia

IL21R antibodies
 

PROTEIN VIEW

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IL21R-001
 
IL21R-003
 
IL21R-006
 
IL21R-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL21R-001 ENSP00000338010
ENST00000337929
Q9HBE5
Show all »
Show » Show » 538 59.1 Yes 1
IL21R-003 ENSP00000379103
ENST00000395754
Q9HBE5
Show all »
Show » Show » 538 59.1 Yes 1
IL21R-006 ENSP00000456707
ENST00000564089
Q9HBE5
Show all »
Show » Show » 538 59.1 Yes 1
IL21R-201 ENSP00000379104
ENST00000395755
Q9HBE5
Show all »
Show » Show » 538 59.1 Yes 1