The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Malignant cells displayed weak to moderate cytoplasmic positivity with additional membranous staining in several tissues. Occasional nuclear staining was observed in thyroid, urothelial, pancreas and liver cancers. A few cases of pancreatic, gastric, breast, prostate, ovary and lung cancer were strongly stained. Most of the malignant melanomas, malignant lymphomas and skin cancers were negative.
Most of the malignant cells displayed weak to moderate cytoplasmic and occasional nuclear positivity. Strong staining was observed in occasional cases of breast and prostate cancers. Cholangiocarcinomas, colorectal, prostate and pancreatic cancers along with a few cases of ovarian and gastric cancers exhibited luminal membranous staining. Several cases of malignant gliomas, testicular, renal, skin and lung cancers were negative.
Validation
Two (or more) antibodies yielding similar or partly similar staining patterns which are partly consistent with or contradicted by limited gene/protein characterization data
Two (or more) antibodies yielding similar or partly similar staining patterns which are partly consistent with or contradicted by limited gene/protein characterization data
