The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Malignancies displayed weak to moderate cytoplasmic and membranous immunoreactivity. Malignant glioma, prostate, endometrial and skin cancers showed cases with strong positivity. Renal cancers and malignant lymphomas were negative or weakly stained.
Most malignant tissues exhibited moderate cytoplasmic and/or membranous positivity. Strong immunoreactivity was observed in several cases of malignant melanomas, endometrial, prostate, skin and urothelial cancers. Malignant lymphomas and gastric cancers were in general negative.
Most malignancies showed moderate cytoplasmic staining often combined with membranous positivity. A majority of squamous cell carcinomas in skin and prostate cancers as well as several malignant melanomas, endometrial and lung cancers were strongly stained. Pancreatic cancers were weakly stained or negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
