TJP1

GENERAL INFORMATION

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Gene name

TJP1

Gene description

Tight junction protein 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Expressed in cell membranes and cytoplasm of most cells, most abundant in endothelial cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA001636 , HPA001637 , CAB010822
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TJP1 (HGNC Symbol)

Synonyms

DKFZp686M05161, MGC133289, ZO-1

Description

Tight junction protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

15

Cytoband

q13.1

Chromosome location (bp)

29699367 - 29968865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104067 (version 78.38)

Entrez gene

7082

UniProt

Q07157 (UniProt - Evidence at protein level)

neXtProt

NX_Q07157

Antibodypedia

TJP1 antibodies


PROTEIN BROWSER

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ENST00000346128
 
ENST00000356107
 
ENST00000400007
 
ENST00000400011
 
ENST00000495972
 
ENST00000545208
 
ENST00000558447
 
ENST00000579042
 
ENST00000614355
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TJP1-001 ENSP00000281537
ENST00000346128
Q07157
Show all »
Show » Show » 1748 195.5 No 0
TJP1-002 ENSP00000382890
ENST00000400011
G5E9E7
Show all »
Show » Show » 1692 189.7 No 0
TJP1-003 ENSP00000452729
ENST00000495972
H0YKB1
Show all »
Show » Show » 383 42.5 No 0
TJP1-007 ENSP00000453334
ENST00000558447
H0YLT6
Show all »
Show » Show » 231 25.9 No 0
TJP1-008 ENSP00000441202
ENST00000545208
Q07157
Show all »
Show » Show » 1668 187 No 0
TJP1-009 ENSP00000348416
ENST00000356107
G3V1L9
Show all »
Show » Show » 1768 197.5 No 0
TJP1-013 ENSP00000382887
ENST00000400007
Show » 227 24.6 No 0
TJP1-014 ENSP00000463194
ENST00000579042
Show » 43 4.4 No 0
TJP1-201 ENSP00000483470
ENST00000614355
B4DZK4
Show all »
Show » Show » 1676 187.8 No 0