The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Moderate to strong cytoplasmic positivity with a granular pattern was observed in most malignant cells. Strong positivity was observed in liver and several colorectal cancers, while testicular cancers, squamous and basal cell carcinomas generally were negative.
Most malignant cells showed moderate cytoplasmic positivity with a granular pattern. Liver and thyroid cancers displayed strong granular cytoplasmic immunoreactivity. Skin cancers were mostly negative.
Most of the malignant cells displayed moderate granular cytoplasmic positivity. A majority of colorectal, thyroid and liver cancers as well as several renal cancers showed strong cytoplasmic immunoreactivity. Most skin, cervical and testicular cancers were negative or showed weak staining.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
