SPAG1

GENE INFORMATION

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Gene name

SPAG1 (HGNC Symbol)

Synonyms

FLJ32920, HSD-3.8, SP75, TPIS

Description

sperm associated antigen 1 (HGNC Symbol)

Entrez gene summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

101170134 - 101271506

Ensembl

ENSG00000104450 (version 73.37)

Entrez gene

6674

UniProt

Q07617 (UniProt - Evidence at protein level)

neXtProt

NX_Q07617

Antibodypedia

SPAG1 antibodies
 

PROTEIN VIEW

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SPAG1-001
 
SPAG1-002
 
SPAG1-004
 
SPAG1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPAG1-001 ENSP00000373450
ENST00000388798
Q07617
Show all »
Show » 926 103.6 No 0
SPAG1-002 ENSP00000427716
ENST00000520643
G3XAM3
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Show » 416 48 No 0
SPAG1-004 ENSP00000428070
ENST00000520508
G3XAM3
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Show » 416 48 No 0
SPAG1-201 ENSP00000251809
ENST00000251809
Q07617
Show all »
Show » 926 103.6 No 0