SARS2

GENE INFORMATION

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Gene name

SARS2 (HGNC Symbol)

Synonyms

FLJ20450, mtSerRS, SARS, SARSM, SerRSmt, SERS, SYS

Description

seryl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

39405906 - 39440495

Ensembl

ENSG00000104835 (version 73.37)

Entrez gene

54938

UniProt

Q9NP81 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NP81

Antibodypedia

SARS2 antibodies
 

PROTEIN VIEW

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SARS2-001
 
SARS2-003
 
SARS2-004
 
SARS2-005
 
SARS2-006
 
SARS2-007
 
SARS2-008
 
SARS2-014
 
SARS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SARS2-001 ENSP00000221431
ENST00000221431
Q9NP81
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Show » Show » 518 58.3 No 0
SARS2-003 ENSP00000472847
ENST00000600042
Q9NP81
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Show » Show » 520 58 No 0
SARS2-004 ENSP00000414954
ENST00000455102
B4DJM9
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Show » 236 26.3 No 0
SARS2-005 ENSP00000406754
ENST00000430193
M0QWZ7
Show all »
Show » 518 58.2 No 0
SARS2-006 ENSP00000472339
ENST00000594171
M0R259
Show all »
Show » Show » 328 36.4 No 0
SARS2-007 ENSP00000472576
ENST00000598343
M0R2H5
Show all »
Show » 135 15.3 No 0
SARS2-008 ENSP00000471767
ENST00000593754
M0R1C0
Show all »
Show » 90 10.3 No 0
SARS2-014 ENSP00000468865
ENST00000598831
M0QX29
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Show » 187 20.5 No 0
SARS2-201 ENSP00000399330
ENST00000448145
E7EX87
Show all »
Show » Show » 518 58.5 No 0