ARHGEF18

GENE INFORMATION

? »

Gene name

ARHGEF18 (HGNC Symbol)

Synonyms

KIAA0521, MGC15913, P114-RhoGEF

Description

Rho/Rac guanine nucleotide exchange factor (GEF) 18 (HGNC Symbol)

Entrez gene summary

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

7459999 - 7537363

Ensembl

ENSG00000104880 (version 73.37)

Entrez gene

23370

UniProt

Q6ZSZ5 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ZSZ5

Antibodypedia

ARHGEF18 antibodies
 

PROTEIN VIEW

? »
 
 
 
ARHGEF18-001
 
ARHGEF18-002
 
ARHGEF18-003
 
ARHGEF18-006
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF18-001 ENSP00000352995
ENST00000359920
Q6ZSZ5
Show all »
Show » 1173 130.8 No 0
ARHGEF18-002 ENSP00000319200
ENST00000319670
Q6ZSZ5
Show all »
Show » 1015 114.1 No 0
ARHGEF18-003 ENSP00000470729
ENST00000594665
Show » 812 91.3 No 0
ARHGEF18-006 ENSP00000471597
ENST00000599752
M0R125
Show all »
87 9.2 No 0