ERCC2

GENE INFORMATION

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Gene name

ERCC2 (HGNC Symbol)

Synonyms

EM9, MAG, MGC102762, MGC126218, MGC126219, XPD

Description

excision repair cross-complementing rodent repair deficiency, complementation group 2 (HGNC Symbol)

Entrez gene summary

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.32

Chromosome location (bp)

45853095 - 45874176

Ensembl

ENSG00000104884 (version 73.37)

Entrez gene

2068

UniProt

P18074 (UniProt - Evidence at protein level)

neXtProt

NX_P18074

Antibodypedia

ERCC2 antibodies
 

PROTEIN VIEW

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ERCC2-001
 
ERCC2-002
 
ERCC2-003
 
ERCC2-004
 
ERCC2-005
 
ERCC2-006
 
ERCC2-011
 
ERCC2-201
 
ERCC2-202
 
ERCC2-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERCC2-001 ENSP00000375809
ENST00000391945
P18074
Show all »
Show » Show » 760 86.9 No 0
ERCC2-002 ENSP00000464887
ENST00000586131
K7EIT8
Show all »
Show » Show » 292 33.4 No 0
ERCC2-003 ENSP00000466998
ENST00000586856
K7ENL1
Show all »
Show » Show » 109 12.7 No 0
ERCC2-004 ENSP00000465593
ENST00000587376
Show » Show » 202 22.5 No 0
ERCC2-005 ENSP00000375805
ENST00000391941
A8MX75
Show all »
Show » Show » 706 80.5 No 0
ERCC2-006 ENSP00000431229
ENST00000485403
P18074
Show all »
Show » Show » 405 46.3 No 0
ERCC2-011 ENSP00000465207
ENST00000591309
B4E0F6
Show all »
Show » Show » 127 14.6 No 0
ERCC2-201 ENSP00000221481
ENST00000221481
B4E0F6
Show all »
Show » Show » 127 14.6 No 0
ERCC2-202 ENSP00000375804
ENST00000391940
P18074
Show all »
Show » Show » 405 46.3 No 0
ERCC2-203 ENSP00000375808
ENST00000391944
E7EVE9
Show all »
Show » Show » 682 77.9 No 0