DOT1L

GENE INFORMATION

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Gene name

DOT1L (HGNC Symbol)

Synonyms

DOT1, KIAA1814, KMT4

Description

DOT1-like histone H3K79 methyltransferase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

2164148 - 2232577

Ensembl

ENSG00000104885 (version 73.37)

Entrez gene

84444

UniProt

Q8TEK3 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TEK3

Antibodypedia

DOT1L antibodies
 

PROTEIN VIEW

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DOT1L-001
 
DOT1L-003
 
DOT1L-006
 
DOT1L-007
 
DOT1L-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOT1L-001 ENSP00000381657
ENST00000398665
Q8TEK3
Show all »
Show » Show » 1537 164.9 No 0
DOT1L-003 ENSP00000404284
ENST00000452696
C9JH95
Show all »
Show » 208 24.3 No 0
DOT1L-006 ENSP00000388276
ENST00000440640
Show » 1210 129.2 No 0
DOT1L-007 ENSP00000412916
ENST00000446286
H7C3N3
Show all »
125 11.9 No 0
DOT1L-008 ENSP00000407411
ENST00000457590
H7C2S2
Show all »
Show » 653 65.5 No 0