CASP14

GENE INFORMATION

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Gene name

CASP14 (HGNC Symbol)

Synonyms

MGC119078, MGC119079, MICE

Description

caspase 14, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.12

Chromosome location (bp)

15160195 - 15169104

Ensembl

ENSG00000105141 (version 73.37)

Entrez gene

23581

UniProt

P31944 (UniProt - Evidence at protein level)

neXtProt

NX_P31944

Antibodypedia

CASP14 antibodies
 

PROTEIN VIEW

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CASP14-001
 
CASP14-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP14-001 ENSP00000393417
ENST00000427043
P31944
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Show » Show » 242 27.7 No 0
CASP14-201 ENSP00000221740
ENST00000221740
P31944
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Show » Show » 242 27.7 No 0