GPI

GENE INFORMATION

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Gene name

GPI (HGNC Symbol)

Synonyms

AMF, NLK

Description

glucose-6-phosphate isomerase (HGNC Symbol)

Entrez gene summary

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.11

Chromosome location (bp)

34850385 - 34893061

Ensembl

ENSG00000105220 (version 73.37)

Entrez gene

2821

UniProt

P06744 (UniProt - Evidence at protein level)

neXtProt

NX_P06744

Antibodypedia

GPI antibodies
 

PROTEIN VIEW

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 « 
 
GPI-001
 
GPI-002
 
GPI-003
 
GPI-004
 
GPI-005
 
GPI-006
 
GPI-007
 
GPI-008
 
GPI-009
 
GPI-012
 
GPI-018
 
GPI-019
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPI-001 ENSP00000405573
ENST00000415930
P06744
Show all »
Show » Show » 569 64.3 No 1
GPI-002 ENSP00000465858
ENST00000588991
P06744
Show all »
Show » Show » 573 64.8 No 2
GPI-003 ENSP00000464797
ENST00000587521
K7EIL4
Show all »
Show » 110 12.7 No 0
GPI-004 ENSP00000466191
ENST00000592277
K7ELR7
Show all »
Show » 146 16.8 No 0
GPI-005 ENSP00000468298
ENST00000587384
K7ERK8
Show all »
Show » 133 15.4 No 0
GPI-006 ENSP00000348877
ENST00000356487
P06744
Show all »
Show » Show » 558 63.1 No 2
GPI-007 ENSP00000464798
ENST00000592144
10 1.2 No 0
GPI-008 ENSP00000467221
ENST00000590375
K7EP41
Show all »
Show » 159 18.3 No 0
GPI-009 ENSP00000468201
ENST00000589399
K7ERC6
Show all »
Show » 162 18.7 No 0
GPI-012 ENSP00000467670
ENST00000586425
K7EP41
Show all »
Show » Show » 474 53.4 No 1
GPI-018 ENSP00000466851
ENST00000591204
Show » 163 18.6 No 0
GPI-019 ENSP00000467590
ENST00000589640
Show » 167 19.2 No 0