PRX

GENERAL INFORMATION

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Gene name

PRX

Gene description

Periaxin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in endothelium and glomeruli, expression in peripheral nerves as well.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA001868
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

PRX (HGNC Symbol)

Synonyms

KIAA1620

Description

Periaxin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

40393768 - 40413366

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105227 (version 78.38)

Entrez gene

57716

UniProt

Q9BXM0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXM0

Antibodypedia

PRX antibodies


PROTEIN BROWSER

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ENST00000291825
 
ENST00000324001
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRX-001 ENSP00000326018
ENST00000324001
Q9BXM0
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Show » Show » 1461 154.9 No 0
PRX-002 ENSP00000291825
ENST00000291825
Q9BXM0
Show all »
Show » Show » 147 15.9 No 0