ICAM4

GENE INFORMATION

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Gene name

ICAM4 (HGNC Symbol)

Synonyms

CD242, LW

Description

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (HGNC Symbol)

Entrez gene summary

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

10397643 - 10399198

Ensembl

ENSG00000105371 (version 73.37)

Entrez gene

3386

UniProt

Q14773 (UniProt - Evidence at transcript level)

neXtProt

NX_Q14773

Antibodypedia

ICAM4 antibodies
 

PROTEIN VIEW

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ICAM4-001
 
ICAM4-002
 
ICAM4-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ICAM4-001 ENSP00000342114
ENST00000340992
Q14773
Show all »
Show » Show » 272 29.6 Yes 0
ICAM4-002 ENSP00000370147
ENST00000380770
Q14773
Show all »
Show » Show » 271 29.3 Yes 1
ICAM4-003 ENSP00000377320
ENST00000393717
Q14773
Show all »
Show » Show » 237 25.9 Yes 0