The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Strong cytoplasmic immunoreactivity was displayed in several cases of colorectal-, stomach-, pancreatic-, lung- and urothelial cancer. Most other tumor types were negative.
Colorectal, stomach, pancreatic, liver, lung, breast, cervical and mucinous cystadenocarcinomas of ovary exhibited strong cytoplasmic, membranous and often extracellular immunoreactivity. Endometrial cancers showed moderate cytoplasmic staining. The remaining tumors were mainly negative.
Most malignant tissues were negative or showed occasional weak to moderate cytoplasmic and membranous immunoreactivity. Some tumors showed a granular staining pattern. A few lung cancers were stronger stained.
Most malignant tissues were in general negative. Colorectal, stomach, few ovarian, cervical, pancreatic and lung cancers showed strong cytoplasmic, membranous and extra cellular positivity.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
The multi-targeting antibody yielding a staining pattern partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data for all of the genes
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
