ATP1A3

GENE INFORMATION

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Gene name

ATP1A3 (HGNC Symbol)

Synonyms

DYT12

Description

ATPase, Na+/K+ transporting, alpha 3 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

42470734 - 42501649

Ensembl

ENSG00000105409 (version 73.37)

Entrez gene

478

UniProt

P13637 (UniProt - Evidence at protein level)

neXtProt

NX_P13637

Antibodypedia

ATP1A3 antibodies
 

PROTEIN VIEW

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ATP1A3-001
 
ATP1A3-002
 
ATP1A3-005
 
ATP1A3-007
 
ATP1A3-008
 
ATP1A3-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1A3-001 ENSP00000302397
ENST00000302102
P13637
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Show » Show » 1013 111.7 No >9
ATP1A3-002 ENSP00000411503
ENST00000441343
M0QXF2
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Show » Show » 1226 133.3 No >9
ATP1A3-005 ENSP00000471581
ENST00000602133
M0R116
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Show » Show » 983 108.3 No >9
ATP1A3-007 ENSP00000437577
ENST00000543770
P13637
Show all »
Show » Show » 1024 113.1 No >9
ATP1A3-008 ENSP00000444688
ENST00000545399
P13637
Show all »
Show » Show » 1026 113.1 No >9
ATP1A3-011 ENSP00000469129
ENST00000473086
M0QXF2
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Show » Show » 178 19.5 No 2