KDELR1

GENERAL INFORMATION

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Gene name

KDELR1

Gene description

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 2 antibodies.
HPA047440 , CAB017455
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

KDELR1 (HGNC Symbol)

Synonyms

ERD2, ERD2.1, HDEL

Description

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (HGNC Symbol)

Entrez gene summary

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

48382570 - 48391553

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105438 (version 78.38)

Entrez gene

10945

UniProt

P24390 (UniProt - Evidence at protein level)

neXtProt

NX_P24390

Antibodypedia

KDELR1 antibodies


PROTEIN BROWSER

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ENST00000330720
 
ENST00000597017
 
ENST00000600980
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDELR1-001 ENSP00000329471
ENST00000330720
P24390
Show all »
Show » Show » 212 24.5 No 7
KDELR1-002 ENSP00000470841
ENST00000597017
P24390
Show all »
Show » Show » 150 17.5 No 4
KDELR1-005 ENSP00000472182
ENST00000600980
M0R1Y2
Show all »
Show » Show » 220 24.8 No 4