HAS1

GENE INFORMATION

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Gene name

HAS1 (HGNC Symbol)

Synonyms

HAS

Description

Hyaluronan synthase 1 (HGNC Symbol)

Entrez gene summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

52216365 - 52227247

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105509 (version 75.37)

Entrez gene

3036

UniProt

Q92839 (UniProt - Evidence at protein level)

neXtProt

NX_Q92839

Antibodypedia

HAS1 antibodies
 

PROTEIN VIEW

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HAS1-001
 
HAS1-002
 
HAS1-003
 
HAS1-004
 
HAS1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAS1-001 ENSP00000445021
ENST00000540069
G3V1S7
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Show » Show » 577 64.7 No 7
HAS1-002 ENSP00000472821
ENST00000601714
M0R2V0
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Show » Show » 585 65.6 No 7
HAS1-003 ENSP00000469165
ENST00000594621
M0QXH4
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Show » 214 23.6 No 0
HAS1-004 ENSP00000471953
ENST00000601667
Q4VHE4
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140 15.9 No 0
HAS1-005 ENSP00000222115
ENST00000222115
Q92839
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Show » Show » 578 64.8 No 7