GCDH

GENE INFORMATION

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Gene name

GCDH (HGNC Symbol)

Synonyms

ACAD5

Description

glutaryl-CoA dehydrogenase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

13001840 - 13025021

Ensembl

ENSG00000105607 (version 73.37)

Entrez gene

2639

UniProt

Q92947 (UniProt - Evidence at protein level)

neXtProt

NX_Q92947

Antibodypedia

GCDH antibodies
 

PROTEIN VIEW

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 « 
 
GCDH-001
 
GCDH-002
 
GCDH-004
 
GCDH-008
 
GCDH-009
 
GCDH-010
 
GCDH-012
 
GCDH-015
 
GCDH-016
 
GCDH-201
 
GCDH-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCDH-001 ENSP00000222214
ENST00000222214
Q92947
Show all »
Show » Show » 438 48.1 No 0
GCDH-002 ENSP00000466845
ENST00000591470
Q92947
Show all »
Show » Show » 438 48.1 No 0
GCDH-004 ENSP00000468452
ENST00000590530
K7ERX1
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Show » Show » 204 22.7 No 0
GCDH-008 ENSP00000465618
ENST00000589039
K7EKH1
Show all »
Show » 148 16.7 No 0
GCDH-009 ENSP00000468125
ENST00000590445
K7ER63
Show all »
86 9.5 No 0
GCDH-010 ENSP00000465770
ENST00000588905
K7EKT3
Show all »
Show » 164 18.4 No 0
GCDH-012 ENSP00000468625
ENST00000590472
Show » 116 12.7 No 0
GCDH-015 ENSP00000468584
ENST00000587072
K7ES74
Show all »
Show » 131 14.5 No 0
GCDH-016 ENSP00000467735
ENST00000591050
Show » 102 10.8 No 0
GCDH-201 ENSP00000394821
ENST00000422947
B4DK85
Show all »
Show » Show » 394 42.3 No 0
GCDH-202 ENSP00000394872
ENST00000457854
Q92947
Show all »
Show » Show » 428 47.4 No 0