JAK3

GENE INFORMATION

? »

Gene name

JAK3 (HGNC Symbol)

Synonyms

JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

Description

Janus kinase 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.11

Chromosome location (bp)

17935589 - 17958880

Ensembl

ENSG00000105639 (version 73.37)

Entrez gene

3718

UniProt

P52333 (UniProt - Evidence at protein level)

neXtProt

NX_P52333

Antibodypedia

JAK3 antibodies
 

PROTEIN VIEW

? »
 
 
 
JAK3-001
 
JAK3-005
 
JAK3-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JAK3-001 ENSP00000436421
ENST00000534444
P52333
Show all »
Show » Show » 1094 121.3 No 0
JAK3-005 ENSP00000432511
ENST00000527670
P52333
Show all »
Show » Show » 1124 125.1 No 0
JAK3-201 ENSP00000391676
ENST00000458235
P52333
Show all »
Show » Show » 1124 125.1 No 0