HAMP

GENE INFORMATION

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Gene name

HAMP (HGNC Symbol)

Synonyms

HEPC, HFE2B, LEAP-1, LEAP1

Description

Hepcidin antimicrobial peptide (HGNC Symbol)

Entrez gene summary

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

35771619 - 35776046

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105697 (version 75.37)

Entrez gene

57817

UniProt

P81172 (UniProt - Evidence at protein level)

neXtProt

NX_P81172

Antibodypedia

HAMP antibodies
 

PROTEIN VIEW

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HAMP-001
 
HAMP-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAMP-001 ENSP00000471894
ENST00000598398
P81172
Show all »
Show » Show » 84 9.4 Yes 0
HAMP-002 ENSP00000222304
ENST00000222304
P81172
Show all »
Show » Show » 84 9.4 Yes 0