HPN

GENERAL INFORMATION

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Gene name

HPN

Gene description

Hepsin

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (kidney, liver)
GTEx:Group enriched (kidney, liver, pancreas)

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic staining was observed in the majority of normal cells. Hepatocytes, exocrine pancreas, gastric chief cells, large intestine and epididymis were strongly stained. Intercalated discs in heart muscle were distinctly stained. Lymphoid tissues were mainly weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA006804
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (kidney, liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (kidney, liver, pancreas)

Organ

Expression



GENE INFORMATION

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Gene name

HPN (HGNC Symbol)

Synonyms

TMPRSS1

Description

Hepsin (HGNC Symbol)

Entrez gene summary

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

19

Cytoband

q13.11

Chromosome location (bp)

35040506 - 35066571

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105707 (version 78.38)

Entrez gene

3249

UniProt

P05981 (UniProt - Evidence at protein level)

neXtProt

NX_P05981

Antibodypedia

HPN antibodies


PROTEIN BROWSER

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ENST00000262626
 
ENST00000392226
 
ENST00000597419
 
ENST00000600390
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HPN-001 ENSP00000376060
ENST00000392226
P05981
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Show » Show » 417 45 No 1
HPN-002 ENSP00000262626
ENST00000262626
P05981
Show all »
Show » Show » 417 45 No 1
HPN-005 ENSP00000470327
ENST00000597419
M0QZ63
Show all »
Show » Show » 259 28.1 No 0
HPN-007 ENSP00000472310
ENST00000600390
M0R244
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Show » Show » 80 8.5 No 0