CDK6

GENE INFORMATION

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Gene name

CDK6 (HGNC Symbol)

Synonyms

PLSTIRE

Description

cyclin-dependent kinase 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

92234235 - 92465908

Ensembl

ENSG00000105810 (version 73.37)

Entrez gene

1021

UniProt

Q00534 (UniProt - Evidence at protein level)

neXtProt

NX_Q00534

Antibodypedia

CDK6 antibodies
 

PROTEIN VIEW

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CDK6-001
 
CDK6-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK6-001 ENSP00000265734
ENST00000265734
Q00534
Show all »
Show » Show » 326 36.9 No 0
CDK6-002 ENSP00000397087
ENST00000424848
Q00534
Show all »
Show » Show » 326 36.9 No 0