PIK3CG

GENE INFORMATION

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Gene name

PIK3CG

Synonyms

Description

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

7 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

106505723 - 106547590

Ensembl

ENSG00000105851 (version 73.37)

Entrez gene

5294

UniProt

P48736 (UniProt - Evidence at protein level)

neXtProt

NX_P48736

Antibodypedia

PIK3CG antibodies
 

PROTEIN VIEW

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PIK3CG-001
 
PIK3CG-002
 
PIK3CG-003
 
PIK3CG-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIK3CG-001 ENSP00000392258
ENST00000440650
P48736
Show all »
Show » Show » 1102 126.5 No 0
PIK3CG-002 ENSP00000419260
ENST00000496166
P48736
Show all »
Show » Show » 1102 126.5 No 0
PIK3CG-003 ENSP00000352121
ENST00000359195
P48736
Show all »
Show » Show » 1102 126.5 No 0
PIK3CG-004 ENSP00000417623
ENST00000473541
E9PDN7
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Show » 182 20.4 No 0