OGDH

GENE INFORMATION

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Gene name

OGDH (HGNC Symbol)

Synonyms

E1k

Description

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (HGNC Symbol)

Entrez gene summary

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Chromosome

7 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

44646171 - 44748665

Ensembl

ENSG00000105953 (version 73.37)

Entrez gene

4967

UniProt

Q02218 (UniProt - Evidence at protein level)

neXtProt

NX_Q02218

Antibodypedia

OGDH antibodies
 

PROTEIN VIEW

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OGDH-001
 
OGDH-002
 
OGDH-003
 
OGDH-005
 
OGDH-006
 
OGDH-007
 
OGDH-008
 
OGDH-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OGDH-001 ENSP00000222673
ENST00000222673
Q02218
Show all »
Show » Show » 1023 115.9 No 0
OGDH-002 ENSP00000392878
ENST00000449767
Q02218
Show all »
Show » Show » 1019 115.5 No 0
OGDH-003 ENSP00000388183
ENST00000447398
E9PDF2
Show all »
Show » 1034 117.2 No 0
OGDH-005 ENSP00000398576
ENST00000439616
E9PFG7
Show all »
Show » 873 99 No 0
OGDH-006 ENSP00000414662
ENST00000444676
E9PCR7
Show all »
Show » Show » 1038 117.7 No 0
OGDH-007 ENSP00000388084
ENST00000443864
Q02218
Show all »
Show » Show » 427 48.2 No 0
OGDH-008 ENSP00000411830
ENST00000419661
C9J4G7
Show all »
Show » 211 23.2 No 0
OGDH-201 ENSP00000443821
ENST00000543843
F5H801
Show all »
Show » 974 110.6 No 0