CAV1

GENE INFORMATION

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Gene name

CAV1 (HGNC Symbol)

Synonyms

CAV

Description

caveolin 1, caveolae protein, 22kDa (HGNC Symbol)

Entrez gene summary

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Chromosome

7 (Chromosome progress)

Cytoband

q31.2

Chromosome location (bp)

116164839 - 116201233

Ensembl

ENSG00000105974 (version 73.37)

Entrez gene

857

UniProt

Q03135 (UniProt - Evidence at protein level)

neXtProt

NX_Q03135

Antibodypedia

CAV1 antibodies
 

PROTEIN VIEW

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CAV1-001
 
CAV1-002
 
CAV1-003
 
CAV1-004
 
CAV1-006
 
CAV1-007
 
CAV1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAV1-001 ENSP00000339191
ENST00000341049
Q03135
Show all »
Show » Show » 178 20.5 No 1
CAV1-002 ENSP00000409541
ENST00000451122
F8WDM7
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86 8.8 No 0
CAV1-003 ENSP00000377110
ENST00000393467
Q03135
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Show » Show » 147 17 No 1
CAV1-004 ENSP00000377111
ENST00000393468
Q03135
Show all »
Show » Show » 147 17 No 1
CAV1-006 ENSP00000377113
ENST00000393470
E9PCT5
Show all »
Show » Show » 167 19.2 No 1
CAV1-007 ENSP00000389033
ENST00000456473
C9JKI3
Show all »
Show » Show » 138 15.9 No 1
CAV1-008 ENSP00000384348
ENST00000405348
Q03135
Show all »
Show » Show » 147 17 No 1