LFNG

GENERAL INFORMATION

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Gene name

LFNG

Gene description

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic, sometimes granular, expression in some tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA069130
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

LFNG (HGNC Symbol)

Synonyms

SCDO3

Description

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (HGNC Symbol)

Entrez gene summary

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

2512529 - 2529177

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106003 (version 78.38)

Entrez gene

3955

UniProt

Q8NES3 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NES3

Antibodypedia

LFNG antibodies


PROTEIN BROWSER

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ENST00000222725
 
ENST00000338732
 
ENST00000359574
 
ENST00000402045
 
ENST00000402506
 
ENST00000614382
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LFNG-001 ENSP00000222725
ENST00000222725
Q8NES3
Show all »
Show » Show » 379 41.8 Yes 0
LFNG-002 ENSP00000352579
ENST00000359574
Q8NES3
Show all »
Show » Show » 361 39.6 Yes 0
LFNG-003 ENSP00000385764
ENST00000402506
Q8NES3
Show all »
Show » Show » 308 35.3 No 0
LFNG-004 ENSP00000384786
ENST00000402045
Q8NES3
Show all »
Show » Show » 250 28.2 No 0
LFNG-201 ENSP00000343095
ENST00000338732
Q8NES3
Show all »
Show » Show » 250 28.2 No 0
LFNG-202 ENSP00000483986
ENST00000614382
Show » Show » 248 28 No 0