BRAT1

GENERAL INFORMATION

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Gene name

BRAT1

Gene description

BRCA1-associated ATM activator 1

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Weak to moderate cytoplasmic staining often combined with nuclear positivity was observed in normal tissues. Renal glomeruli and endothelial cells displayed strong membranous and cytoplasmic staining. Glial cells and most lymphoid cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA029455
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BRAT1 (HGNC Symbol)

Synonyms

BAAT1, C7orf27, MGC22916

Description

BRCA1-associated ATM activator 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

2537877 - 2555727

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106009 (version 78.38)

Entrez gene

221927

UniProt

Q6PJG6 (UniProt - Evidence at protein level)

neXtProt

NX_Q6PJG6

Antibodypedia

BRAT1 antibodies


PROTEIN BROWSER

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ENST00000340611
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRAT1-001 ENSP00000339637
ENST00000340611
Q6PJG6
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