BRAT1

GENE INFORMATION

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Gene name

BRAT1 (HGNC Symbol)

Synonyms

BAAT1, C7orf27, MGC22916

Description

BRCA1-associated ATM activator 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

Chromosome

7 (Chromosome progress)

Cytoband

p22.3

Chromosome location (bp)

2577511 - 2595361

Ensembl

ENSG00000106009 (version 73.37)

Entrez gene

221927

UniProt

Q6PJG6 (UniProt - Evidence at protein level)

neXtProt

NX_Q6PJG6

Antibodypedia

BRAT1 antibodies
 

PROTEIN VIEW

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BRAT1-001
 
BRAT1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRAT1-001 ENSP00000339637
ENST00000340611
Q6PJG6
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Show » Show » 821 88.1 No 0
BRAT1-005 ENSP00000409209
ENST00000421712
F8WDN5
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143 15.4 No 0