CHN2

GENERAL INFORMATION

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Gene name

CHN2

Gene description

Chimerin 2

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Group enriched (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate to strong cytoplasmic positivity in granular pattern. Glial cells of CNS were weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA018989
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

CHN2 (HGNC Symbol)

Synonyms

ARHGAP3, RhoGAP3

Description

Chimerin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

29122274 - 29514328

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106069 (version 78.38)

Entrez gene

1124

UniProt

P52757 (UniProt - Evidence at protein level)

neXtProt

NX_P52757

Antibodypedia

CHN2 antibodies


PROTEIN BROWSER

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ENST00000222792
 
ENST00000409041
 
ENST00000409350
 
ENST00000421775
 
ENST00000423511
 
ENST00000424025
 
ENST00000433720
 
ENST00000435288
 
ENST00000439384
 
ENST00000439711
 
ENST00000446446
 
ENST00000495789
 
ENST00000539389
 
ENST00000539406
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHN2-001 ENSP00000222792
ENST00000222792
P52757
Show all »
Show » Show » 468 53.9 No 0
CHN2-005 ENSP00000398326
ENST00000433720
Show » Show » 91 10.3 No 0
CHN2-009 ENSP00000386968
ENST00000409350
B8ZZU1
Show all »
Show » 174 20 No 0
CHN2-010 ENSP00000409843
ENST00000439384
C9JQ94
Show all »
Show » 187 21.3 No 0
CHN2-018 ENSP00000396867
ENST00000446446
H7C0V3
Show all »
Show » Show » 180 20.6 No 0
CHN2-020 ENSP00000462650
ENST00000423511
J3KSU2
Show all »
Show » 37 4 No 0
CHN2-201 ENSP00000386849
ENST00000409041
B3VCF5
Show all »
Show » Show » 260 30.1 No 0
CHN2-202 ENSP00000394284
ENST00000421775
P52757
Show all »
Show » Show » 274 31.5 No 0
CHN2-203 ENSP00000406337
ENST00000424025
B3VCF4
Show all »
Show » Show » 228 26.4 No 0
CHN2-204 ENSP00000400282
ENST00000435288
B3VCG2
Show all »
Show » Show » 124 14.4 No 0
CHN2-205 ENSP00000387425
ENST00000439711
B3VCF6
Show all »
Show » Show » 197 22.6 No 0
CHN2-206 ENSP00000438587
ENST00000495789
B3VCG5
Show all »
Show » 216 24.9 No 0
CHN2-207 ENSP00000440526
ENST00000539389
Show » Show » 189 21.7 No 0
CHN2-208 ENSP00000444063
ENST00000539406
B3VCG4
Show all »
Show » Show » 182 21.1 No 0