CHN2

GENE INFORMATION

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Gene name

CHN2 (HGNC Symbol)

Synonyms

ARHGAP3, RhoGAP3

Description

chimerin 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

p14.3

Chromosome location (bp)

29161956 - 29553944

Ensembl

ENSG00000106069 (version 73.37)

Entrez gene

1124

UniProt

P52757 (UniProt - Evidence at protein level)

neXtProt

NX_P52757

Antibodypedia

CHN2 antibodies
 

PROTEIN VIEW

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 « 
 
CHN2-001
 
CHN2-005
 
CHN2-009
 
CHN2-010
 
CHN2-017
 
CHN2-018
 
CHN2-020
 
CHN2-201
 
CHN2-202
 
CHN2-203
 
CHN2-204
 
CHN2-205
 
CHN2-206
 
CHN2-207
 
CHN2-208
 
CHN2-209
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHN2-001 ENSP00000222792
ENST00000222792
P52757
Show all »
Show » Show » 468 53.9 No 0
CHN2-005 ENSP00000398326
ENST00000433720
Show » 91 10.3 No 0
CHN2-009 ENSP00000386968
ENST00000409350
B8ZZU1
Show all »
Show » Show » 174 20 No 0
CHN2-010 ENSP00000409843
ENST00000439384
C9JQ94
Show all »
Show » Show » 187 21.3 No 0
CHN2-017 ENSP00000441183
ENST00000474070
136 15.3 No 0
CHN2-018 ENSP00000396867
ENST00000446446
H7C0V3
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Show » 180 20.6 No 0
CHN2-020 ENSP00000462650
ENST00000423511
J3KSU2
Show all »
37 4 No 0
CHN2-201 ENSP00000386849
ENST00000409041
P52757
Show all »
Show » 332 38.2 No 0
CHN2-202 ENSP00000394284
ENST00000421775
B3VCF3
Show all »
Show » 274 31.5 No 0
CHN2-203 ENSP00000406337
ENST00000424025
B3VCF1
Show all »
Show » 287 33.1 No 0
CHN2-204 ENSP00000400282
ENST00000435288
F5GWP4
Show all »
Show » Show » 192 22.1 No 0
CHN2-205 ENSP00000387425
ENST00000439711
B3VCF7
Show all »
Show » 286 33.1 No 0
CHN2-206 ENSP00000438587
ENST00000495789
B7Z1V0
Show all »
Show » Show » 481 55.5 No 0
CHN2-207 ENSP00000440526
ENST00000539389
B3VCG1
Show all »
Show » 324 37.2 No 0
CHN2-208 ENSP00000444063
ENST00000539406
F5H003
Show all »
Show » Show » 543 62.4 No 0
CHN2-209 ENSP00000442812
ENST00000546235
B7Z1W9
Show all »
Show » Show » 453 52.6 No 0