CASP2

GENE INFORMATION

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Gene name

CASP2 (HGNC Symbol)

Synonyms

ICH1, NEDD2, PPP1R57

Description

caspase 2, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

7 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

142985308 - 143004789

Ensembl

ENSG00000106144 (version 73.37)

Entrez gene

835

UniProt

P42575 (UniProt - Evidence at protein level)

neXtProt

NX_P42575

Antibodypedia

CASP2 antibodies
 

PROTEIN VIEW

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CASP2-001
 
CASP2-003
 
CASP2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP2-001 ENSP00000312664
ENST00000310447
P42575
Show all »
Show » Show » 452 50.7 No 0
CASP2-003 ENSP00000340030
ENST00000350623
Show » 108 12.1 No 0
CASP2-005 ENSP00000376656
ENST00000392925
C9JRR9
Show all »
Show » 171 19.1 No 0