The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Strong cytoplasmic positivity was observed in liver, while small intestine, smooth muscle and connective tissues, as well as a subset of cells in renal glomeruli were moderately stained. Essentially all other normal tissues were negative.
Most normal tissues showed weak to moderate cytoplasmic positivity with additional nuclear/membranous staining in few. Decidual cells showed strong cytoplasmic staining while few glandular cells in stomach showed strong cytoplasmic and membranous immunoreactivity. Lymphoid tissues, liver, uterine cervix, trophoblastic cells, islets of Langerhans, urothelium, fallopian tubes, salivary glands and renal glomeruli were generally negative.
A majority of normal tissues displayed weak to moderate cytoplasmic immunoreactivity. Additional nuclear staining was observed in CNS. Glandular cells in stomach showed strong cytoplasmic positivity. Lymphoid tissues and squamous epithelia were negative.