GCK

GENE INFORMATION

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Gene name

GCK (HGNC Symbol)

Synonyms

HK4, MODY2

Description

glucokinase (hexokinase 4) (HGNC Symbol)

Entrez gene summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Chromosome

7 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

44183872 - 44237769

Ensembl

ENSG00000106633 (version 73.37)

Entrez gene

2645

UniProt

P35557 (UniProt - Evidence at protein level)

neXtProt

NX_P35557

Antibodypedia

GCK antibodies
 

PROTEIN VIEW

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GCK-001
 
GCK-002
 
GCK-003
 
GCK-004
 
GCK-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCK-001 ENSP00000384247
ENST00000403799
P35557
Show all »
Show » Show » 465 52.2 No 0
GCK-002 ENSP00000223366
ENST00000345378
P35557
Show all »
Show » Show » 466 52.1 No 0
GCK-003 ENSP00000379142
ENST00000395796
P35557
Show all »
Show » Show » 464 52 No 0
GCK-004 ENSP00000402840
ENST00000437084
C9JQD1
Show all »
Show » Show » 448 50.1 No 0
GCK-006 ENSP00000338009
ENST00000336642
H7BXV0
Show all »
Show » 149 15.9 No 0