LIMK1

GENE INFORMATION

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Gene name

LIMK1 (HGNC Symbol)

Synonyms

LIMK

Description

LIM domain kinase 1 (HGNC Symbol)

Entrez gene summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Chromosome

7 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

73497263 - 73536855

Ensembl

ENSG00000106683 (version 73.37)

Entrez gene

3984

UniProt

P53667 (UniProt - Evidence at protein level)

neXtProt

NX_P53667

Antibodypedia

LIMK1 antibodies
 

PROTEIN VIEW

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LIMK1-001
 
LIMK1-002
 
LIMK1-003
 
LIMK1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIMK1-001 ENSP00000336740
ENST00000336180
P53667
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Show » Show » 647 72.6 No 0
LIMK1-002 ENSP00000409717
ENST00000418310
E9PC47
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Show » 677 75.5 No 0
LIMK1-003 ENSP00000414606
ENST00000435201
P53667
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Show » Show » 305 33.4 No 0
LIMK1-005 ENSP00000444452
ENST00000538333
P53667
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Show » Show » 613 68.7 No 0