C5

GENE INFORMATION

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Gene name

C5 (HGNC Symbol)

Synonyms

C5a, C5b, CPAMD4

Description

complement component 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Chromosome

9 (Chromosome progress)

Cytoband

q33.2

Chromosome location (bp)

123714616 - 123812554

Ensembl

ENSG00000106804 (version 73.37)

Entrez gene

727

UniProt

P01031 (UniProt - Evidence at protein level)

neXtProt

NX_P01031

Antibodypedia

C5 antibodies
 

PROTEIN VIEW

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C5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C5-001 ENSP00000223642
ENST00000223642
P01031
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