ASPN

GENE INFORMATION

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Gene name

ASPN (HGNC Symbol)

Synonyms

FLJ20129, PLAP1, SLRR1C

Description

asporin (HGNC Symbol)

Entrez gene summary

This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Chromosome

9 (Chromosome progress)

Cytoband

q22.31

Chromosome location (bp)

95218487 - 95244788

Ensembl

ENSG00000106819 (version 73.37)

Entrez gene

54829

UniProt

Q9BXN1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXN1

Antibodypedia

ASPN antibodies
 

PROTEIN VIEW

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ASPN-001
 
ASPN-002
 
ASPN-201
 
ASPN-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASPN-001 ENSP00000364694
ENST00000375544
Q9BXN1
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Show » 380 43.4 Yes 0
ASPN-002 ENSP00000364693
ENST00000375543
Q5TBF2
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Show » 243 27.7 Yes 0
ASPN-201 ENSP00000378909
ENST00000395538
C9JGC9
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Show » 243 27.8 Yes 0
ASPN-202 ENSP00000389902
ENST00000450139
Q05CQ6
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80 9.2 No 0