DOCK8

GENERAL INFORMATION

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Gene name

DOCK8

Gene description

Dedicator of cytokinesis 8

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Urothelium, cells in seminiferus ducts, prostate, trophoblastic cells, bone marrow poietic cells and a subset of lymphoid cells showed moderate nuclear and cytoplasmic staining. Remaining normal tissues showed weak cytoplasmic positivity or were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003218
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

DOCK8 (HGNC Symbol)

Synonyms

FLJ00026, FLJ00152, FLJ00346, ZIR8

Description

Dedicator of cytokinesis 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]

Chromosome

9

Cytoband

p24.3

Chromosome location (bp)

214854 - 465259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107099 (version 78.38)

Entrez gene

81704

UniProt

Q8NF50 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NF50

Antibodypedia

DOCK8 antibodies


PROTEIN BROWSER

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ENST00000382329
 
ENST00000382331
 
ENST00000432829
 
ENST00000453981
 
ENST00000469391
 
ENST00000479404
 
ENST00000487230
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK8-001 ENSP00000394888
ENST00000432829
Q8NF50
Show all »
Show » Show » 2099 238.5 No 0
DOCK8-005 ENSP00000371766
ENST00000382329
A2A369
Show all »
Show » Show » 1566 178 No 0
DOCK8-009 ENSP00000371768
ENST00000382331
A2A370
Show all »
Show » Show » 439 49.5 No 0
DOCK8-012 ENSP00000419438
ENST00000469391
Q8NF50
Show all »
Show » Show » 1999 227.5 No 0
DOCK8-013 ENSP00000417082
ENST00000479404
C9J613
Show all »
Show » Show » 66 7.7 No 0
DOCK8-014 ENSP00000418318
ENST00000487230
C9J7A3
Show all »
Show » Show » 107 12.2 No 0
DOCK8-201 ENSP00000408464
ENST00000453981
Q8NF50
Show all »
Show » Show » 2031 230.8 No 0