DOCK8

GENE INFORMATION

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Gene name

DOCK8 (HGNC Symbol)

Synonyms

FLJ00026, FLJ00152, FLJ00346, ZIR8

Description

dedicator of cytokinesis 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]

Chromosome

9 (Chromosome progress)

Cytoband

p24.3

Chromosome location (bp)

214854 - 465259

Ensembl

ENSG00000107099 (version 73.37)

Entrez gene

81704

UniProt

Q8NF50 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NF50

Antibodypedia

DOCK8 antibodies
 

PROTEIN VIEW

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DOCK8-001
 
DOCK8-004
 
DOCK8-005
 
DOCK8-008
 
DOCK8-009
 
DOCK8-012
 
DOCK8-013
 
DOCK8-014
 
DOCK8-018
 
DOCK8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK8-001 ENSP00000408464
ENST00000453981
Q8NF50
Show all »
Show » Show » 2099 238.5 No 0
DOCK8-004 ENSP00000417691
ENST00000483757
E9PDJ4
Show all »
Show » 502 56.9 No 0
DOCK8-005 ENSP00000371766
ENST00000382329
A2A369
Show all »
Show » Show » 1566 178 No 0
DOCK8-008 ENSP00000418587
ENST00000469197
F8WC95
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66 7.5 No 0
DOCK8-009 ENSP00000371768
ENST00000382331
A2A370
Show all »
Show » Show » 439 49.5 No 0
DOCK8-012 ENSP00000419438
ENST00000469391
Q8NF50
Show all »
Show » Show » 1999 227.5 No 0
DOCK8-013 ENSP00000417082
ENST00000479404
C9J613
Show all »
Show » 66 7.7 No 0
DOCK8-014 ENSP00000418318
ENST00000487230
C9J7A3
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Show » 107 12.2 No 0
DOCK8-018 ENSP00000436628
ENST00000524396
E9PHZ4
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50 5.2 No 0
DOCK8-201 ENSP00000394888
ENST00000432829
Q8NF50
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Show » Show » 2031 230.8 No 0